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Synfacts 2010(2): 0250-0250  
DOI: 10.1055/s-0029-1219049
Polymer-Supported Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Preparation of 2H-1,4-Benzoxazin-2-one Derivatives

Contributor(s): Yasuhiro Uozumi, Yoichi M. A. Yamada, Chung Keun Jin
R. Ballini*, A. Palmieri*, M. A. Talaq, S. Gabrielli
University of Camerino, Italy and Anbar University, Iraq
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Publication History

Publication Date:
21 January 2010 (online)

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Significance

The preparation of 2H-1,4-benz­oxazin-2-one derivatives with a basic anion exchange resin (carbonate form) was described. Thus, the hetero-Michael addition of 2-aminophenols 2 (1 mmol) to β-nitroacrylates 1 (1 mmol) was carried out with Amberlite IRA-900 (NaCO3 - form) (1 mmol) in EtOAc (2 mL) at 55 ˚C to give the corresponding products 6 (13 examples, 45-90% yields).